Cu(II) and Zn(II)have been implicated in the misfolding of A-beta in vivo. Ab binds Cu(II) via three Histidine residues (His6, 13 and 14), and our studies also implicate the N-terminus as the fourth ligand in a square planar complex (1)

(1) C. D. Syme, R. C. Nadal, S. E. J. Rigby and J.H. Viles, Journal of Biological Chemistry (2004), in press