Publications by Dr. John Viles

Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: The unstructured N-terminus facilitates the coordination of six Cu2+ ions at physiological concentrations.
C. E. Jones, M. Klewpatinond, S. R. Abdelraheim, David R. Brown and John H. Viles
(2005) J Mol Biol 346, 1393-1407

Preferential copper2+ coordination by His96 and His111 induces ?-sheet formation in the unstructured amyloidogenic region of the prion protein.
Christopher E. Jones, Salama R. Abdelraheim, David R. Brown and John H. Viles
(2004) J. Biol. Chem. 279, 32018-32027

Copper binding to the amyloid-beta (A?) peptide associated with Alzheimer’s disease.
Christopher D. Syme, Rebecca C. Nadal, Stephen E. J. Rigby and John H. Viles
(2004) J. Biol. Chem. 279, 18169-18177

Copper binding to the octarepeats of the prion protein. Affinity, specificity, folding, and cooperativity: insights from circular dichroism.
J Biol Chem. 2003 Feb 28;278(9):6795-802
Garnett AP, Viles JH

Potential bias in NMR relaxation data introduced by peak intensity analysis and curve fitting methods.
J Biomol NMR. 2001 Sep;21(1):1-9
Viles JH, Duggan BM, Zaborowski E, Schwarzinger S, Huntley JJ, Kroon GJ, Dyson HJ, Wright PE

Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics.
Biochemistry. 2001 Mar 6;40(9):2743-53
Viles JH, Donne D, Kroon G, Prusiner SB, Cohen FE, Dyson HJ, Wright PE

Copper binding to the prion protein: structural implications of four identical cooperative binding sites.
Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2042-7
Viles JH, Cohen FE, Prusiner SB, Goodin DB, Wright PE, Dyson HJ

Design, synthesis and structure of a zinc finger with an artificial beta-turn.
J Mol Biol. 1998 Jun 19;279(4):973-86
Viles JH, Patel SU, Mitchell JB, Moody CM, Justice DE, Uppenbrink J, Doyle PM, Harris CJ, Sadler PJ, Thornton JM

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible.
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13452-7
Donne DG, Viles JH, Groth D, Mehlhorn I, James TL, Cohen FE, Prusiner SB, Wright PE, Dyson HJ

Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides.
Eur J Biochem. 1996 Dec 1;242(2):352-62
Viles JH, Mitchell JB, Gough SL, Doyle PM, Harris CJ, Sadler PJ, Thornton JM

Observation of albumin resonances in proton nuclear magnetic resonance spectra of human blood plasma: N-terminal assignments aided by use of modified recombinant albumin.
Analyst. 1996 Jul;121(7):913-22
Harris R, Patel SU, Sadler PJ, Viles JH

Solution structure of a biologically active cyclic LDV peptide analogue containing a type II' beta-turn mimetic.
Int J Pept Protein Res. 1996 Jun;47(6):427-36
Doyle PM, Harris JC, Moody CM, Sadler PJ, Sims M, Thornton JM, Uppenbrink J, Viles JH

Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an alpha-helical protein with over 50% sequence identity to an all-beta protein.
Proteins. 1996 Apr;24(4):502-13
Jones DT, Moody CM, Uppenbrink J, Viles JH, Doyle PM, Harris CJ, Pearl LH, Sadler PJ, Thornton JM

1H and (113)Cd NMR Investigations of Cd(2+) and Zn(2+) Binding Sites on Serum Albumin: Competition with Ca(2+), Ni(2+), Cu(2+), and Zn(2+).
Inorg Chem. 1996 Jul 17;35(15):4490-4496
Sadler PJ, Viles JH

Involvement of a lysine residue in the N-terminal Ni2+ and Cu2+ binding site of serum albumins. Comparison with Co2+, Cd2+ and Al3+.
Eur J Biochem. 1994 Feb 15;220(1):193-200
Sadler PJ, Tucker A, Viles JH